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Nucleic Acids In Chemistry And Biology Pdf

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The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA.

The reversible and noncovalent nature of the interactions governing the structure and binding properties of nucleic acids mean that the fields of supramolecular chemistry and nucleic acid chemistry are closely intertwined. Indeed, the high fidelity and programmable molecular recognition properties of DNA have Indeed, the high fidelity and programmable molecular recognition properties of DNA have long been the source of inspiration to many a supramolecular chemist in designing molecular assemblies that are both discrete in shape and dynamic in nature.

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Last reviewed: November An acidic, chainlike biological macromolecule consisting of multiple repeated units of phosphoric acid, sugar, and purine and pyrimidine bases. Nucleic acids Fig. Each DNA strand is a long polymeric molecule consisting of many individual nucleotides linked end to end. The great size and complexity of DNAs are indicated by their molecular weights, which commonly range in the hundreds of millions.

Nucleic acid

A free online book on the chemistry and biology of nucleic acids, written by Prof. The book is ideal for chemistry and biology students and also provides practical information for researchers working in the lab. Contact us About us Privacy policy Terms and conditions Legal information. Oligo synthesis custom oligonucleotides Research and development About us who we are Book on nucleic acids Oligo calculator oligonucleotide properties. Nucleic Acids Book A free online book on the chemistry and biology of nucleic acids, written by Prof. Nucleic acid structure.

Nucleic acids are the biopolymers , or large biomolecules , essential to all known forms of life. They are composed of nucleotides , which are the monomers made of three components: a 5-carbon sugar , a phosphate group and a nitrogenous base. If the sugar is a compound ribose , the polymer is RNA ribonucleic acid ; if the sugar is derived from ribose as deoxyribose , the polymer is DNA deoxyribonucleic acid. Nucleic acids are naturally occurring chemical compounds that serve as the primary information-carrying molecules in cells. They play an especially important role in directing protein synthesis.

This unique and practical resource provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. Its focus is on a survey of structures especially important for biomedical research and pharmacological applications. To aid novices, Principles of Nucleic Acid Structure includes an introduction to technical lingo used to describe nucleic acid structure and conformations roll, slide, twist, buckle, etc. This completely updated edition features expanded coverage of the latest advances relevant to recognition of DNA and RNA by small molecules and proteins. This handy guide ends with a complete list of resources, including relevant online databases and software.


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Chemical Biology of Nucleic Acids

This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research. Skip to main content Skip to table of contents. Advertisement Hide.

Vester, L. Lundberg, M.

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Chemical Biology of Nucleic Acids

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Pascaline M. 03.06.2021 at 02:38

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