File Name: microbial genetics and molecular biology textbook .zip
This module is designed to consolidate and expand knowledge of microbial genetics and virology obtained in year 2. Students should gain an understanding of how bacterial genetic material can be altered, by mutation, horizontal gene transfer and programmed gene rearrangements.
William Astbury described molecular biology in in Nature , as:. It is concerned particularly with the forms of biological molecules and [ It must at the same time inquire into genesis and function. Some clinical research and medical therapies arising from molecular biology are covered under gene therapy whereas the use of molecular biology or molecular cell biology in medicine is now referred to as molecular medicine.
The field of molecular biology studies macromolecules and the macromolecular mechanisms found in living things, such as the molecular nature of the gene and its mechanisms of gene replication, mutation, and expression. Despite its prominence in the contemporary life sciences, molecular biology is a relatively young discipline, originating in the s and s, and becoming institutionalized in the s and s. It should not be surprising, then, that many of the philosophical issues in molecular biology are closely intertwined with this recent history. The rich historiography of molecular biology can only be briefly utilized in this shortened history see, for example, Abir-Am , , , ; Burian a; Canguillhem ; de Chadarevian , ; de Chadarevian and Gaudilliere ; de Chadarevian and Strasser ; Deichmann ; Fisher ; Hausmann ; Holmes ; Judson , ; Kay ; Marcum ; Morange a, ; Olby , , , ; Powell et al. Also see autobiographical accounts by biologists, such as Brenner ; Cohen ; Crick ; Echols ; Jacob ; Kornberg ; Luria ; Watson , , ; Wilkins The field of molecular biology arose from the convergence of work by geneticists, physicists, and structural chemists on a common problem: the nature of inheritance. Thomas Hunt Morgan and his colleagues utilized the fruit fly, Drosophila melanogaster , as a model organism to study the relationship between the gene and the chromosomes in the hereditary process Morgan ; discussed in Darden ; Darden and Maull ; Kohler ; Roll-Hanson ; Wimsatt
Between and , a new phenomenon emerged in the field of bacteriology. And yet, to describe bacteria as sexually reproducing organisms, the definition of sex itself had to change. Despite manifold contradictions and the availability of alternative language, the notion of sexually active even promiscuous single-celled organisms has persisted, even into contemporary textbooks on cell biology and genetics. This is a preview of subscription content, access via your institution. Rent this article via DeepDyve. Adelberg, Edward A. Boston: Little, Brown and Co.
Molecular Biology: Academic Cell Update provides an introduction to the fundamental concepts of molecular biology and its applications. It deliberately covers a broad range of topics to show that molecular biology is applicable to human medicine and health, as well as veterinary medicine, evolution, agriculture, and other areas. The present Update includes journal specific images and test bank. It also offers vocabulary flashcards. The book begins by defining some basic concepts in genetics such as biochemical pathways, phenotypes and genotypes, chromosomes, and alleles. It also describes genetic processes such as transcription, recombination and repair, regulation, and mutations.
Bacteriophages viruses that infect bacteria are fascinating organisms that have played and continue to play a key role in bacterial genetics and molecular biology. Phage can confer key phenotypes on their host, for example converting a non-pathogenic strain into a pathogen, and they play a key role in regulating bacterial populations in all sorts of environments. The phage-bacterium relationship varies enormously: from the simple predator-prey model to a complex, almost symbiotic relationship that promotes the survival and evolutionary success of both. In fact interest in phage and phage gene products as potential therapeutic agents is increasing rapidly and is likely to have a profound impact on the pharmaceutical industry and biotechnology in general over the coming years. One potential application is the use of phage to combat the growing menace of antibiotic-resistant infections.
NCBI Bookshelf. Molecular Biology of the Cell. New York: Garland Science;
In Genetics Maloy, Stanley and John R. Arrangement and rearrangement of the bacterial chromosome. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with Microbiology Chapter 8 Microbial Genetics. Design a set of experiments that could be used to place a newly discovered cellular microbe on a phylogenetic tree based on small subunit SSU rRNA sequences 3.
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